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Wt1tm1.1Ndha
Targeted Allele Detail
Nomenclature
Symbol: Wt1tm1.1Ndha
Name: Wilms tumor 1 homolog; targeted mutation 1.1, Nicholas D Hastie
MGI ID: MGI:4849364
Synonyms: Wt1co, Wt1loxP
Gene: Wt1  Location: Chr2:105126529-105173614 bp, + strand  Genetic Position: Chr2, 55.06 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166573
Parent Cell Line:  E14TG2aIV (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1, and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:166573)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wt1 Mutation:  12 strains or lines available
References
Original:  J:166573 Martinez-Estrada OM, et al., Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nat Genet. 2010 Jan;42(1):89-93
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory