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Dnm2tm1.1Ics
Targeted Allele Detail
Nomenclature
Symbol: Dnm2tm1.1Ics
Name: dynamin 2; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:4848043
Synonyms: Dnm2R465W
Gene: Dnm2  Location: Chr9:21424908-21507759 bp, + strand  Genetic Position: Chr9, 7.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166364
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 11 was replaced with one in which an A to T transversion results in the amino acid substitution of tryptophan for arginine at position 465 (R465W). A floxed neo cassette inserted downstream of the modified exon 11 was removed by cre-mediated recombination. (J:166364)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnm2 Mutation:  52 strains or lines available
References
Original:  J:166364 Durieux AC, et al., A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice. Hum Mol Genet. 2010 Dec 15;19(24):4820-36
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory