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Nphs2tm3.1Antc
Targeted Allele Detail
Nomenclature
Symbol: Nphs2tm3.1Antc
Name: nephrosis 2, podocin; targeted mutation 3.1, Corinne Antignac
MGI ID: MGI:4845889
Gene: Nphs2  Location: Chr1:156310727-156328035 bp, + strand  Genetic Position: Chr1, 67.71 cM, cytoband G3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166320
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2, and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:166320)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nphs2 Mutation:  14 strains or lines available
References
Original:  J:166320 Mollet G, et al., Podocin inactivation in mature kidneys causes focal segmental glomerulosclerosis and nephrotic syndrome. J Am Soc Nephrol. 2009 Oct;20(10):2181-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory