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Targeted Allele Detail
Symbol: Pik3cbtm1.1Rzl
Name: phosphatidylinositol 3-kinase, catalytic, beta polypeptide; targeted mutation 1.1, Richard Z Lin
MGI ID: MGI:4845857
Synonyms: p110betaflox, pik3cb3/4 loxP, Pik3cbFlox
Gene: Pik3cb  Location: Chr9:99036654-99140621 bp, - strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:166421
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3, and an FRT and loxP flanked neo cassette was inserted downstream of exon 4. Flp mediated recombination removed the neo cassette leaving exons 3 and 4 floxed. (J:166421)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3cb Mutation:  101 strains or lines available
Original:  J:166421 Lu Z, et al., Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction. Circulation. 2009 Jul 28;120(4):318-25
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
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