About   Help   FAQ
Sh2d1b1/Sh2d1b2tm1.1Cpt
Targeted Allele Detail
Nomenclature
Symbol: Sh2d1b1/Sh2d1b2tm1.1Cpt
Name: SH2 domain containing 1B1; targeted mutation 1.1, Cox Terhorst
MGI ID: MGI:4840395
Synonyms: EAT-2A/B-
Gene: Sh2d1b1  Location: Chr1:170277320-170286769 bp, + strand  Genetic Position: Chr1, 76.84 cM, cytoband H2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166054
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsExon 1 of Sh2d1b1 was replaced with a floxed neo cassette while exon 1 of Sh2d1b2 was replaced with a hygro cassette with a 5' loxP site. Cre mediated recombination removed the intervening sequence. (J:166054)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d1b1 Mutation:  4 strains or lines available
References
Original:  J:166054 Wang N, et al., Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse. J Immunol. 2010 Nov 15;185(10):5683-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/12/2017
MGI 6.10
The Jackson Laboratory