Tnfrsf11a^tm1Kost
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11a^tm1Kost
• Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1, Paul J Kostenuik
• MGI ID: MGI:4840355
• Synonyms: huRANKL
• Gene: Tnfrsf11a Location: Chr1:105708443-105775709 bp, + strand Genetic Position: Chr1, 49.7 cM
• Alliance: Tnfrsf11a^tm1Kost page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166279
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region of the endogenous exon 5 of the mouse gene was replaced with the coding region of the human gene. A floxed PGK-neomycin selection cassette wa also inserted downstream of exon 5. (J:166279)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf11a Mutation: 42 strains or lines available

References

• Original: J:166279 Kostenuik PJ, et al., Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL. J Bone Miner Res. 2009 Feb;24(2):182-95
• All: 2 reference(s)