Mcl1^tm1Dmta
Targeted Allele Detail

Summary

• Symbol: Mcl1^tm1Dmta
• Name: myeloid cell leukemia sequence 1; targeted mutation 1, David M Tarlinton
• MGI ID: MGI:4840274
• Synonyms: mcl-1^fl, Mcl1^flN
• Gene: Mcl1 Location: Chr3:95566099-95570487 bp, + strand Genetic Position: Chr3, 40.74 cM
• Alliance: Mcl1^tm1Dmta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166069
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the start codon and a human CD4 cDNA with a 5' loxP site and an FRT-flanked neo cassette was inserted downstream of the stop codon. (J:166069)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcl1 Mutation: 33 strains or lines available

References

• Original: J:166069 Vikstrom I, et al., Mcl-1 is essential for germinal center formation and B cell memory. Science. 2010 Nov 19;330(6007):1095-9
• All: 24 reference(s)