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Lmnatm7Lgf
Targeted Allele Detail
Nomenclature
Symbol: Lmnatm7Lgf
Name: lamin A; targeted mutation 7, Loren G Fong
MGI ID: MGI:4840061
Synonyms: LmnaLAO
Gene: Lmna  Location: Chr3:88480147-88509956 bp, - strand  Genetic Position: Chr3, 38.84 cM
Misshapen cell nuclei in embryonic Lmnatm7Lgf/Lmnatm7Lgf fibroblasts

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165928
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 10, 11, and 12 (and the introns between) were replaced with the corresponding cDNA without the last 30 nucleotides of exon 11 and the first 24 nucleotides of exon 12 to bring the last codon of mature lamin A adjacent to the prelamin A stop codon. This allele is predicted to produce only the mature lamin A isoform. (J:165928)
Generation of the Lmnatm7Lgf allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmna Mutation:  57 strains or lines available
References
Original:  J:165928 Coffinier C, et al., Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. J Biol Chem. 2010 Jul 2;285(27):20818-26
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory