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Meg3tm1Itl
Targeted Allele Detail
Nomenclature
Symbol: Meg3tm1Itl
Name: maternally expressed 3; targeted mutation 1, inGenious Targeting Laboratory
MGI ID: MGI:4840060
Synonyms: Meg3tm1Igl
Gene: Meg3  Location: Chr12:109541001-109571726 bp, + strand  Genetic Position: Chr12, 60.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166176
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 5.9 kb region spanning from about 300 bp upstream of exon 1 to downstream of exon 5 was replaced with a neo cassette via homologous recombination. This deletion includes part but not all of the upstream differentially methylated region. (J:166176)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Meg3 Mutation:  1 strain or line available
References
Original:  J:166176 Zhou Y, et al., Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development. 2010 Aug;137(16):2643-52
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory