Ctsh^tm1Thre
Targeted Allele Detail

Summary

• Symbol: Ctsh^tm1Thre
• Name: cathepsin H; targeted mutation 1, Thomas Reinheckel
• MGI ID: MGI:4840055
• Synonyms: CatH^-
• Gene: Ctsh Location: Chr9:89936320-89958148 bp, + strand Genetic Position: Chr9, 47.4 cM
• Alliance: Ctsh^tm1Thre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165930
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exons 5 through 9 were replaced with an IRES, lacZ gene, and neo cassette. The absence of transcript expression was confirmed by northern blot analysis on liver and kidney extracts. (J:165930, J:178096)

Generation of the Ctsh^tm1Thre allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsh Mutation: 28 strains or lines available

References

• Original: J:165930 D'Angelo ME, et al., Cathepsin H is an additional convertase of pro-granzyme B. J Biol Chem. 2010 Jul 2;285(27):20514-9
• All: 7 reference(s)