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Pknox1tm1Fbla
Targeted Allele Detail
Nomenclature
Symbol: Pknox1tm1Fbla
Name: Pbx/knotted 1 homeobox; targeted mutation 1, Francesco Blasi
MGI ID: MGI:4839363
Gene: Pknox1  Location: Chr17:31564749-31607684 bp, + strand  Genetic Position: Chr17, 16.78 cM, cytoband B-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165811
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 7 and 8 were replaced with a splice acceptor beta-geo cassette. The absence of protein expression was confirmed by western blot analysis on embryonic stem cell extracts. (J:165811)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pknox1 Mutation:  59 strains or lines available
References
Original:  J:165811 Fernandez-Diaz LC, et al., The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells. Development. 2010 Oct;137(20):3393-403
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory