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Toxtm1Kay
Targeted Allele Detail
Summary
Symbol: Toxtm1Kay
Name: thymocyte selection-associated high mobility group box; targeted mutation 1, Jonathan Kaye
MGI ID: MGI:4839072
Gene: Tox  Location: Chr4:6686353-6991557 bp, - strand  Genetic Position: Chr4, 3.04 cM
Alliance: Toxtm1Kay page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164687
Parent Cell Line:  CMTI-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 1. After transient cre-expression cells were selected for elimination of the selectable marker cassettes but maintenance of loxP-flanked exon 1. (J:131287, J:164687)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tox Mutation:  36 strains or lines available
References
Original:  J:131287 Aliahmad P, et al., Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 2008 Jan 21;205(1):245-56
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory