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Targeted Allele Detail
Symbol: Fbn1tm1.2Lysa
Name: fibrillin 1; targeted mutation 1.2, Lynn Y Sakai
MGI ID: MGI:4839045
Synonyms: GT8
Gene: Fbn1  Location: Chr2:125300594-125507993 bp, - strand  Genetic Position: Chr2, 61.38 cM, cytoband F
Fragmentation of aortic root elastic lamellae in Fbn1tm1.2Lysa/Fbn1+ mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:165897
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Inversion
  Fbn1tm1.2Lysa involves 1 genes/genome features (Fbn1) View all
Mutation detailsA lox66 site was inserted upstream of exon 33. The following vector was inserted into intron 34 (5' through 3'): eGFP, exon 33 splice acceptor site, lox77 site, and FRT flanked neo cassette. Flp mediated recombination removed the neo cassette. Cre mediated recombination inverted the region between lox66 and lox77, bringing eGFP into frame after exon 32. The predicted product is truncated after the 17th calcium-binding epidermal growth factor-like domain (cbEGF17) and called GT8 ("green truncated" from founder mouse 8). (J:165897)
Generation of the Fbn1tm1.2Lysa allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbn1 Mutation:  69 strains or lines available
Original:  J:165897 Charbonneau NL, et al., In vivo studies of mutant fibrillin-1 microfibrils. J Biol Chem. 2010 Aug 6;285(32):24943-55
All:  1 reference(s)

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MGI 6.03
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