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Targeted Allele Detail
Symbol: Clec1btm1.1Ksi
Name: C-type lectin domain family 1, member b; targeted mutation 1.1, Katsue Suzuki-Inoue
MGI ID: MGI:4839037
Gene: Clec1b  Location: Chr6:129397297-129409335 bp, + strand  Genetic Position: Chr6, 63.3 cM, cytoband F3
Lymphatic function is impaired in Clec1btm1.1Ksi/Clec1btm1.1Ksi embryos

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:165898
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre mediated recombination removed part of exon 1 while leaving the neo cassette intact. (J:165898)
Generation of the Clec1btm1Ksi and Clec1btm1.1Ksi alleles
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clec1b Mutation:  6 strains or lines available
Original:  J:165898 Suzuki-Inoue K, et al., Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem. 2010 Aug 6;285(32):24494-507
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory