Cxcl12^{tm3.1(HBEGF/EGFP)Tng}
Targeted Allele Detail

Summary

• Symbol: Cxcl12^{tm3.1(HBEGF/EGFP)Tng}
• Name: C-X-C motif chemokine ligand 12; targeted mutation 3.1, Takashi Nagasawa
• MGI ID: MGI:4838646
• Synonyms: CXCL12-DTR-GFP
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^{tm3.1(HBEGF/EGFP)Tng} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164657
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Cxcl12^{tm3.1(HBEGF/EGFP)Tng} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The coding region of exon 1 was replaced with human HBEGF (Diphtheria toxin receptor) fused to EGFP and a floxed neo cassette. Cre mediated recombination removed the neo cassette. This allele allows for conditional ablation of Cxcl12-expressing cells following treatment with Diphtheria toxin. (J:164657)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 24 strains or lines available

References

• Original: J:164657 Omatsu Y, et al., The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010 Sep 24;33(3):387-99
• All: 1 reference(s)