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Cdh1tm1Cle
Targeted Allele Detail
Nomenclature
Symbol: Cdh1tm1Cle
Name: cadherin 1; targeted mutation 1, Hans Clevers
MGI ID: MGI:4838590
Synonyms: EcadCFP, E-cadherin-mCFP
Gene: Cdh1  Location: Chr8:106603351-106670246 bp, + strand  Genetic Position: Chr8, 53.18 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164644
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsMonomeric cyan fluorescent protein (mCFP) and a loxP-flanked neomycin cassette were targeted to exon 16 (encoding the endogenous STOP codon) to maintain normal expression levels and patterns. (J:164644)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdh1 Mutation:  120 strains or lines available
References
Original:  J:164644 Snippert HJ, et al., Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 2010 Oct 1;143(1):134-44
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory