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Targeted Allele Detail
Symbol: Nox4tm1.1Ams
Name: NADPH oxidase 4; targeted mutation 1.1, Ajay M Shah
MGI ID: MGI:4838549
Gene: Nox4  Location: Chr7:87246096-87398710 bp, + strand  Genetic Position: Chr7, 48.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:165541
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Recombinase mediated recombination removed exons 1 and 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the hearts and kidneys of homozygous mice. (J:165541)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nox4 Mutation:  31 strains or lines available
Original:  J:165541 Zhang M, et al., NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18121-6
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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