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Targeted Allele Detail
Symbol: Sh2d3ctm1.1Ebp
Name: SH2 domain containing 3C; targeted mutation 1.1, Elena Pasquale
MGI ID: MGI:4838039
Gene: Sh2d3c  Location: Chr2:32721055-32755512 bp, + strand  Genetic Position: Chr2, 22.09 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:165694
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre mediated recombination removed exon 7 and the neo cassette. The absence of full-length and presence of truncated (489 and 462 amino acids) protein expression were confirmed by western blot analysis on brain and lung extracts. (J:165694)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d3c Mutation:  17 strains or lines available
Original:  J:165694 Roselli S, et al., The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas. Cell Signal. 2010 Nov;22(11):1745-52
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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