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Cyp2a5tm1Ding
Targeted Allele Detail
Nomenclature
Symbol: Cyp2a5tm1Ding
Name: cytochrome P450, family 2, subfamily a, polypeptide 5; targeted mutation 1, Xinxin Ding
MGI ID: MGI:4837923
Synonyms: Cyp2a5-null
Gene: Cyp2a5  Location: Chr7:26534764-26542689 bp, + strand  Genetic Position: Chr7, 15.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:165695
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 9 was replaced with a loxP site flanked neomycin resistance gene cassette. The absence of transcript expression was confirmed by RT-PCR on olfactory mucosa, liver, lung, kidney, and testis extracts. (J:165695)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp2a5 Mutation:  22 strains or lines available
References
Original:  J:165695 Zhou X, et al., Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model. J Pharmacol Exp Ther. 2010 Feb;332(2):578-87
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory