Ncoa6^tm3Jxu
Targeted Allele Detail

Summary

• Symbol: Ncoa6^tm3Jxu
• Name: nuclear receptor coactivator 6; targeted mutation 3, Jianming Xu
• MGI ID: MGI:4837687
• Synonyms: Ncoa6^f, Ncoa6^flox, Ncoa6^loxP
• Gene: Ncoa6 Location: Chr2:155232585-155315741 bp, - strand Genetic Position: Chr2, 77.26 cM, cytoband H2
• Alliance: Ncoa6^tm3Jxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165054
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 8 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:165054, J:189065)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa6 Mutation: 100 strains or lines available

References

• Original: J:165054 Wang WL, et al., Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15;21(14):2453-68
• All: 3 reference(s)