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Targeted Allele Detail
Symbol: Ncoa6tm3Jxu
Name: nuclear receptor coactivator 6; targeted mutation 3, Jianming Xu
MGI ID: MGI:4837687
Synonyms: Ncoa6f, Ncoa6flox, Ncoa6loxP
Gene: Ncoa6  Location: Chr2:155390656-155473894 bp, - strand  Genetic Position: Chr2, 77.26 cM, cytoband H2
Germline Transmission:  Earliest citation of germline transmission: J:165054
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 8 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 8 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:165054, J:189065)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncoa6 Mutation:  79 strains or lines available
Original:  J:165054 Wang WL, et al., Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15;21(14):2453-68
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory