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Targeted Allele Detail
Symbol: Myh6tm3.1Jse
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 3.1, Jonathan G Seidman
MGI ID: MGI:4837367
Synonyms: alpha-MHC719, RW
Gene: Myh6  Location: Chr14:54941921-54966927 bp, - strand  Genetic Position: Chr14, 28.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:165269
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 19 was replaced with a modified one containing nucleotide substitutions that result the amino acid substitution of arginine with tryphtophan at position 719 (R719W). A floxed neo cassette inserted downstream of exon 19 was removed by cre mediated recombination. (J:165269)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh6 Mutation:  28 strains or lines available
Original:  J:165269 Teekakirikul P, et al., Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-beta. J Clin Invest. 2010 Oct 1;120(10):3520-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory