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Targeted Allele Detail
Symbol: Hspa4tm1.1Miv
Name: heat shock protein 4; targeted mutation 1.1, Nahid F Mivechi
MGI ID: MGI:4836945
Synonyms: hsp110-
Gene: Hspa4  Location: Chr11:53259814-53300457 bp, - strand  Genetic Position: Chr11, 31.91 cM
Germline Transmission:  Earliest citation of germline transmission: J:164904
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with a lacZ gene and floxed neo cassette. Cre mediated recombination removed the neo cassette. The absence of full length product and production of beta-galactosidase was confirmed by western blot analysis of brain extracts. (J:164904)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspa4 Mutation:  57 strains or lines available
Original:  J:164904 Eroglu B, et al., Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta. Mol Cell Biol. 2010 Oct;30(19):4626-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory