Trpv3^tm1.2Clph
Targeted Allele Detail

Summary

• Symbol: Trpv3^tm1.2Clph
• Name: transient receptor potential cation channel, subfamily V, member 3; targeted mutation 1.2, David E Clapham
• MGI ID: MGI:4836903
• Synonyms: V3 KO
• Gene: Trpv3 Location: Chr11:73158315-73191194 bp, + strand Genetic Position: Chr11, 45.25 cM
• Alliance: Trpv3^tm1.2Clph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164741
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two loxP sites flanking exon 13 and a FRT-flanked neomycin resistance cassette were inserted within intron 13 by homologous recombination. The selection cassette and exon 13 were removed by flp and cre mediated recombination. (J:164741)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv3 Mutation: 54 strains or lines available

References

• Original: J:164741 Cheng X, et al., TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010 Apr 16;141(2):331-43
• All: 3 reference(s)