Has1^tm1Nita
Targeted Allele Detail

Summary

• Symbol: Has1^tm1Nita
• Name: hyaluronan synthase 1; targeted mutation 1, Naoki Itano
• MGI ID: MGI:4835713
• Gene: Has1 Location: Chr17:18063588-18075450 bp, - strand Genetic Position: Chr17, 10.53 cM
• Alliance: Has1^tm1Nita page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Part of exon 5 was replaced with a neomycin selection cassette by homologous recombination. (J:164205)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Has1 Mutation: 28 strains or lines available

References

• Original: J:164205 Kobayashi N, et al., Hyaluronan deficiency in tumor stroma impairs macrophage trafficking and tumor neovascularization. Cancer Res. 2010 Sep 15;70(18):7073-83
• All: 15 reference(s)