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Chd7tm1.1Dmm
Targeted Allele Detail
Nomenclature
Symbol: Chd7tm1.1Dmm
Name: chromodomain helicase DNA binding protein 7; targeted mutation 1.1, Donna M Martin
MGI ID: MGI:4835266
Synonyms: Chd7flox
Gene: Chd7  Location: Chr4:8690406-8867659 bp, + strand  Genetic Position: Chr4, 3.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:164582
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted up stream of exon 2 and an FRT flanked neo/kan cassette and second loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo/kan cassette. (J:164582)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chd7 Mutation:  41 strains or lines available
References
Original:  J:164582 Hurd EA, et al., The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development. 2010 Sep;137(18):3139-50
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory