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Tg(MMTV-LPAR3)3Gbm
Transgene Detail
Summary
Symbol: Tg(MMTV-LPAR3)3Gbm
Name: transgene insertion 3, Gordon B Mills
MGI ID: MGI:4835238
Synonyms: LPA3-L3
Transgene: Tg(MMTV-LPAR3)3Gbm  Location: unknown  
Alliance: Tg(MMTV-LPAR3)3Gbm page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MMTV-LPAR3)3Gbm expresses 1 gene
 
Mutation detailsThe MMTV-lpa3 transgenic construct contains the 1.54 kb MMTV LTR and the full-length cDNA of FLAG-tagged human LPA3 receptor linked to the KCR fragment containing the exon II (E2), intron II (I2), exon III (E3), and polyadenylation signal (rbGpA) derived from rabbit beta-globin. Two MMTV-lpa3 (#LPA3-3 and #LPA3-22) founders passed the transgene through the germ line. (J:149661)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(MMTV-LPAR3)3Gbm
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:149661 Liu S, et al., Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell. 2009 Jun 2;15(6):539-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory