Clcn4^tm1Tjj
Targeted Allele Detail

Summary

• Symbol: Clcn4^tm1Tjj
• Name: chloride channel, voltage-sensitive 4; targeted mutation 1, Thomas J Jentsch
• MGI ID: MGI:4834490
• Gene: Clcn4 Location: Chr7:7285308-7303837 bp, - strand Genetic Position: Chr7, 4.23 cM, cytoband A2
• Alliance: Clcn4^tm1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164474
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 5 and 6 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on kidney extracts. (J:164474)

Generation of the Clcn4^tm1Tjj allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn4 Mutation: 53 strains or lines available

References

• Original: J:164474 Rickheit G, et al., Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation. J Biol Chem. 2010 Jun 4;285(23):17595-603
• All: 2 reference(s)