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Actbtm1(INSR)Dac
Targeted Allele Detail
Nomenclature
Symbol: Actbtm1(INSR)Dac
Name: actin, beta; targeted mutation 1, Dominico Accili
MGI ID: MGI:4831148
Synonyms: beta/INSR
Gene: Actb  Location: Chr5:142903115-142906754 bp, - strand  Genetic Position: Chr5, 81.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91350
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, No functional change)
Mutation:    Insertion
 
Actbtm1(INSR)Dac expresses 1 gene
 
Mutation detailsAn IRES, floxed neomycin selection cassette with a polyadenylation signal, and a human insulin receptor cDNA were inserted downstream of the stop codon of the endogenous gene. Expression of the inserted INSR cDNA requires cre excision of the neomycin cassette. (J:91350)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Actb Mutation:  19 strains or lines available
References
Original:  J:91350 Okamoto H, et al., Transgenic rescue of insulin receptor-deficient mice. J Clin Invest. 2004 Jul;114(2):214-23
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory