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Targeted Allele Detail
Symbol: Macf1tm2.1Liem
Name: microtubule-actin crosslinking factor 1; targeted mutation 2.1, Ronald K H Liem
MGI ID: MGI:4831018
Synonyms: Macf1F
Gene: Macf1  Location: Chr4:123349633-123684360 bp, - strand  Genetic Position: Chr4, 57.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:164146
Parent Cell Line:  CSL3 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 6 and a floxed neo cassette was inserted downstream of exon 7. Cre mediated recombination removed the neo cassette leaving exons 6 and 7 floxed. (J:164146)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Macf1 Mutation:  510 strains or lines available
Original:  J:164146 Goryunov D, et al., Nervous-tissue-specific elimination of microtubule-actin crosslinking factor 1a results in multiple developmental defects in the mouse brain. Mol Cell Neurosci. 2010 May;44(1):1-14
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory