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Cyp1a1tm4.1Dwn
Targeted Allele Detail
Nomenclature
Symbol: Cyp1a1tm4.1Dwn
Name: cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 4.1, Daniel W Nebert
MGI ID: MGI:4830524
Synonyms: Cyp1a1mtp
Gene: Cyp1a1  Location: Chr9:57595211-57611107 bp, + strand  Genetic Position: Chr9, 31.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163973
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 2 was replaced with a modified exon 2 in which nucleotide substitutions (CTT to AAT at codon 7 and CTC to AAC at codon 17) result in the amino acid substitutions of asparagine for leucine at positions 7 and 17 (L7N and L17N) in the SRP-binding and ER transmembrane anchor/stop transfer sequence. A floxed neo cassette inserted upstream of the modified exon was removed by cre mediated recombination. The product is predicted to undergo mitochondrial proteolysis targeting. (J:163973)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp1a1 Mutation:  26 strains or lines available
References
Original:  J:163973 Dong H, et al., Knock-in mouse lines expressing either mitochondrial or microsomal CYP1A1: differing responses to dietary benzo[a]pyrene as proof of principle. Mol Pharmacol. 2009 Mar;75(3):555-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory