Hap1^tm2Xjl
Targeted Allele Detail

Summary

• Symbol: Hap1^tm2Xjl
• Name: huntingtin-associated protein 1; targeted mutation 2, Xiao-Jiang Li
• MGI ID: MGI:4830316
• Gene: Hap1 Location: Chr11:100238153-100246954 bp, - strand Genetic Position: Chr11, 63.47 cM, cytoband D
• Alliance: Hap1^tm2Xjl page

Reduced body weight in Hap1^tm2Xjl/Hap1^tm2Xjl Tg(HCRT-cre)1Stak/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163896
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exon 1 was floxed and a neomycin resistance cassette was inserted together with the loxP sequence in the 3' flanking intron of exon1. (J:163896)

Generation of the Hap1^tm2Xjl allele

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hap1 Mutation: 37 strains or lines available

References

• Original: J:163896 Lin YF, et al., Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice. J Biol Chem. 2010 May 21;285(21):15941-9
• All: 6 reference(s)