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Targeted Allele Detail
Symbol: Eif4etm1.1Lfur
Name: eukaryotic translation initiation factor 4E; targeted mutation 1.1, Luc Furic
MGI ID: MGI:4830310
Synonyms: eIF4ES209A
Gene: Eif4e  Location: Chr3:138526179-138559696 bp, + strand  Genetic Position: Chr3, 64.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:163589
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 8 was replaced with one in which nucleotide substitutions result in the amino acid substitution of alanine for serine at position 209 (S209A). A floxed neo cassette inserted upstream of the modified exon was removed by cre mediated recombination. (J:163589)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eif4e Mutation:  30 strains or lines available
Original:  J:163589 Furic L, et al., eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14134-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory