Esr1^tm1.1Pws
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1.1Pws
• Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Philip W Shaul
• MGI ID: MGI:4829939
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1.1Pws page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre mediated recombination removed exon 3. The absence of expression was confirmed in all tissues. (J:163783)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 67 strains or lines available

References

• Original: J:163783 Chambliss KL, et al., Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest. 2010 Jul 1;120(7):2319-30
• All: 1 reference(s)