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Tnfaip3tm1.2Gvl
Targeted Allele Detail
Nomenclature
Symbol: Tnfaip3tm1.2Gvl
Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1.2, Geert van Loo
MGI ID: MGI:4829664
Gene: Tnfaip3  Location: Chr10:19000910-19015657 bp, - strand  Genetic Position: Chr10, 8.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163410
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre mediated recombination removed exons 4 and 5. The absence of protein expression was confirmed by western blot analysis on colonic epithelial extracts. (J:163410)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfaip3 Mutation:  18 strains or lines available
References
Original:  J:163410 Vereecke L, et al., Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis. J Exp Med. 2010 Jul 5;207(7):1513-23
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory