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Jak2tm1.1Jlvl
Targeted Allele Detail
Nomenclature
Symbol: Jak2tm1.1Jlvl
Name: Janus kinase 2; targeted mutation 1.1, Jean-Luc Villeval
MGI ID: MGI:4829538
Synonyms: Jak2V617F
Gene: Jak2  Location: Chr19:29251828-29313080 bp, + strand  Genetic Position: Chr19, 23.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163497
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 13 was replaced with one in which a G to T mutation results in an amino acid substitution of phenylalanine for valine at position 617 (V617F). An FRT flanked neo cassette downstream of the modified exon was removed by flp mediated recombination. (J:163497)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Jak2 Mutation:  5 strains or lines available
References
Original:  J:163497 Marty C, et al., Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice. Blood. 2010 Aug 5;116(5):783-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory