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Sorbs3tm1Kiok
Targeted Allele Detail
Nomenclature
Symbol: Sorbs3tm1Kiok
Name: sorbin and SH3 domain containing 3; targeted mutation 1, Noriyuki Kioka
MGI ID: MGI:4822403
Synonyms: vinexin-
Gene: Sorbs3  Location: Chr14:70180468-70207637 bp, - strand  Genetic Position: Chr14, 36.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162344
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of an intron and an exon encoding the first SH3 domain which is shared by all known vinexin variants was replaced with a neo cassette by targeted recombination. Absence of alpha and beta variants of the vinexin protein was confirmed by Western blot. (J:162344)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sorbs3 Mutation:  13 strains or lines available
References
Original:  J:162344 Kioka N, et al., Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo. Exp Cell Res. 2010 Jun 10;316(10):1728-38
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory