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Targeted Allele Detail
Symbol: Apptm3.2Umu
Name: amyloid beta (A4) precursor protein; targeted mutation 3.2, Ulrike Muller
MGI ID: MGI:4822178
Synonyms: Apptm3.2Mull
Gene: App  Location: Chr16:84952666-85173952 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Germline Transmission:  Earliest citation of germline transmission: J:163059
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo resistance cassette was inserted 5' to exon 1 as well as an additional loxP site within intron 1 by homologous recombination. The neo cassette and exon 1 were removed by cre mediated recombination. Western blot analysis revealed the absence of any detectable protein expression. (J:163059)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:  31 strains or lines available
Original:  J:163059 Mallm JP, et al., Generation of conditional null alleles for APP and APLP2. Genesis. 2010 Mar;48(3):200-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory