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Gt(ROSA)26Sortm2(Foxo1)Jnk
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm2(Foxo1)Jnk
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jun Nakae
MGI ID: MGI:4820847
Synonyms: R26floxneoCNFoxO1
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162892
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm2(Foxo1)Jnk expresses 1 gene
 
Mutation detailsAn expression cassette containing a floxed neo-STOP cassette followed by a constitutively nuclear (CN), FLAG-tagged mouse cDNA (alanine substitutions T24A/S253A/S316A) was inserted into the locus. Cre mediated expression is required to achieve expression of the truncated cDNA. (J:162892)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  258 strains or lines available
References
Original:  J:162892 Iskandar K, et al., PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E787-98
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory