Pdpn^tm1(cre)Mlkn
Targeted Allele Detail

Summary

• Symbol: Pdpn^tm1(cre)Mlkn
• Name: podoplanin; targeted mutation 1, Mark L Kahn
• MGI ID: MGI:4820841
• Synonyms: Pdpn^Cre
• Gene: Pdpn Location: Chr4:142994001-143026134 bp, - strand Genetic Position: Chr4, 77.29 cM
• Alliance: Pdpn^tm1(cre)Mlkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162815
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutation: Insertion
• Pdpn^tm1(cre)Mlkn expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdpn (MGI:103098)

• Mutation details: Exon 1 of Pdpn was replaced with the cre cDNA and an FRT-flanked neo cassette, generating a null allele. RT-PCR performed on E14 embryos demonstrated complete loss of Pdpn mRNA. (J:162815)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdpn (mouse) Summary of all recombinase alleles driven by Pdpn. Alliance mouse Pdpn gene page

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpn Mutation: 28 strains or lines available

References

• Original: J:162815 Bertozzi CC, et al., Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010 Jul 29;116(4):661-70
• All: 1 reference(s)