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Spontaneous Allele Detail
Symbol: Traf3ip2adjm
Name: TRAF3 interacting protein 2; atopic dermatitis from Japanese mice
MGI ID: MGI:4820827
Gene: Traf3ip2  Location: Chr10:39612934-39655307 bp, + strand  Genetic Position: Chr10, 20.86 cM
Strain of Origin:  KOR
Allele Type:    Spontaneous
Mutation:    Nucleotide substitutions
Mutation detailsA spontaneous mutation resulted in a C to T transition in the second exon. The transition results in a C- terminal truncation by changing amino acid 214 from glutamine (CAG) to a stop codon (TAG). RT-PCR showed reduced transcript level and western blots of protein extracts from spleens showed no specific Ab labeling in the positions expected for TRAF3IP2.
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Traf3ip2 Mutation:  34 strains or lines available
Original:  J:162859 Matsushima Y, et al., An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene. J Immunol. 2010 Aug 15;185(4):2340-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory