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Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
Transgene Detail
Nomenclature
Symbol: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro
Name: transgene insertion, Carlo M Croce
MGI ID: MGI:4820820
Synonyms: Emu-miR-29, Tg(Emu-Mir29a,-Mir29b-1,-hrGFP)#Cro
Transgene: Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro expresses 2 genes
 
Mutation detailsThe mouse Igh (VH186.2) promoter and the IgH-E mu enhancer drive the expression of Mir29a and Mir29b-1, followed by an IRES-hrGFP, humanized renilla, and the SV40 poly (A).Northern blot analysis using RNAs isolated from spleens showed overexpression of Mir-29a and Mir-29b-1 in both transgenic lines (F1 and F2). This line is a represntative line. (J:162077)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:162077 Santanam U, et al., Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12210-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory