Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Brigid L Hogan |
MGI ID: |
MGI:4820800 |
Synonyms: |
Gt(Rosa)26Sortm1/Sox2/blh, Rosa26RSox2-IRES-GFP, ROSA26-SOX2 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:161806
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(CAG-Sox2,-EGFP)Blh expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Sox2 (MGI:98364) |
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Mutation details: A CAG promoter drives expression of the mouse cDNA and IRES-EGFP preceded by a floxed neo-STOP cassette. Cre mediated recombination is necessary to achieve expression of the mouse cDNA and reporter cassette.
(J:161806)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
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Original: |
J:161806 Lu Y, et al., Evidence that SOX2 overexpression is oncogenic in the lung. PLoS One. 2010;5(6):e11022 |
All: |
10 reference(s) |
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