Slc4a11^tm1Boet
Targeted Allele Detail

Summary

• Symbol: Slc4a11^tm1Boet
• Name: solute carrier family 4, sodium bicarbonate transporter-like, member 11; targeted mutation 1, Thomas Boettger
• MGI ID: MGI:4820767
• Gene: Slc4a11 Location: Chr2:130526033-130539439 bp, - strand Genetic Position: Chr2, 63.24 cM
• Alliance: Slc4a11^tm1Boet page

Altered cornea morphology in Slc4a11^tm1Boet/Slc4a11^tm1Boet mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion A beta-geo cassette was fused to exon 10. (J:162968)

Generation of the Slc4a11^tm1Boet allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a11 Mutation: 50 strains or lines available

References

• Original: J:162968 Groger N, et al., SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria. J Biol Chem. 2010 May 7;285(19):14467-74
• All: 1 reference(s)