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Psmg1tm1.1Smta
Targeted Allele Detail
Nomenclature
Symbol: Psmg1tm1.1Smta
Name: proteasome (prosome, macropain) assembly chaperone 1; targeted mutation 1.1, Shigeo Murata
MGI ID: MGI:4820728
Synonyms: Psmg1F
Gene: Psmg1  Location: Chr16:95979935-95990903 bp, - strand  Genetic Position: Chr16, 56.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162790
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:162790)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Psmg1 Mutation:  4 strains or lines available
References
Original:  J:162790 Sasaki K, et al., PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Mol Cell Biol. 2010 Aug;30(15):3864-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory