Lepr^tm3.1Yli
Targeted Allele Detail

Summary

• Symbol: Lepr^tm3.1Yli
• Name: leptin receptor; targeted mutation 3.1, Yong Liu
• MGI ID: MGI:4820542
• Synonyms: Ob-Rb^F985, Y985F
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^tm3.1Yli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161732
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The tyrosine 985 residue in exon 18 was replaced with phenylalanine and a floxed neo cassette was inserted after exon 18 via homologous recombination. The floxed neo cassette was then removed by cre mediated recombination leaving behind a single loxP site. (J:161732)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 121 strains or lines available

References

• Original: J:161732 You J, et al., Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance. Mol Cell Biol. 2010 Apr;30(7):1650-9
• All: 1 reference(s)