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Il1rntm1.1Cga
Targeted Allele Detail
Nomenclature
Symbol: Il1rntm1.1Cga
Name: interleukin 1 receptor antagonist; targeted mutation 1.1, Cem Gabay
MGI ID: MGI:4819784
Synonyms: IL-1Raflx
Gene: Il1rn  Location: Chr2:24336860-24351491 bp, + strand  Genetic Position: Chr2, 16.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:162760
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2 was flanked with loxP sites. Flp mediated recombination removed the FRT flanked neo cassette upstream of exon 2. (J:162760)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il1rn Mutation:  9 strains or lines available
References
Original:  J:162760 Lamacchia C, et al., Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist. Arthritis Rheum. 2010 Feb;62(2):452-62
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory