Tg(Myh6-TNNT2*R92Q)#Ajm
Transgene Detail

Summary

• Symbol: Tg(Myh6-TNNT2*R92Q)#Ajm
• Name: transgene insertion, Ali J Marian
• MGI ID: MGI:4819720
• Synonyms: cTnT-Q92, cTnT-Q⁹²
• Transgene: Tg(Myh6-TNNT2*R92Q)#Ajm Location: unknown
• Alliance: Tg(Myh6-TNNT2*R92Q)#Ajm page

Transgene origin

• Strain of Origin: C3H and C57BL/6 and ICR

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-TNNT2*R92Q)#Ajm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNNT2 (7139)

  Tnnt2

  (MGI:104597)

• Mutation details: This transgene consists of a 5.5 Kb fragment of the murine Myh6 promoter driving expression of a full length human TNNT2 cDNA containing a G to A substitution that results in an Arg 92 Gln mutation. (J:161899)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:162685 Lim DS, et al., Angiotensin II blockade reverses myocardial fibrosis in a transgenic mouse model of human hypertrophic cardiomyopathy. Circulation. 2001 Feb 13;103(6):789-91
• All: 3 reference(s)