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Tg(Tnnt2-TNNT2*R92Q)M-2Ajm
Transgene Detail
Nomenclature
Symbol: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm
Name: transgene insertion M-2, Ali J Marian
MGI ID: MGI:4819719
Synonyms: cTnT-Q92
Transgene: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm  Location: unknown  
Transgene
origin
Strain of Origin:  C3H and C57BL/6 and ICR
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tnnt2-TNNT2*R92Q)M-2Ajm expresses 1 gene
 
Mutation detailsThis transgene consists of a -497 bp fragment of the mouse Tnnt2 promoter driving expression of a full length human TNNT2 cDNA containing a G to A substitution that results in an Arg 92 Gln mutation. Five lines were generated (M-1, M-2, M-3, M-4. M-5). In this line (M-2) transgene transcript and protein make up 15% and 9%, respectively, of the total TNNT2 pool. (J:117554)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:117554 Oberst L, et al., Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice. J Clin Invest. 1998 Oct 15;102(8):1498-505
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory