About   Help   FAQ
Transgene Detail
Symbol: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm
Name: transgene insertion M-2, Ali J Marian
MGI ID: MGI:4819719
Synonyms: cTnT-Q92
Transgene: Tg(Tnnt2-TNNT2*R92Q)M-2Ajm  Location: unknown  
Strain of Origin:  C3H and C57BL/6 and ICR
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Tnnt2-TNNT2*R92Q)M-2Ajm expresses 1 gene
Mutation detailsThis transgene consists of a -497 bp fragment of the mouse Tnnt2 promoter driving expression of a full length human TNNT2 cDNA containing a G to A substitution that results in an Arg 92 Gln mutation. Five lines were generated (M-1, M-2, M-3, M-4. M-5). In this line (M-2) transgene transcript and protein make up 15% and 9%, respectively, of the total TNNT2 pool. (J:117554)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:117554 Oberst L, et al., Dominant-negative effect of a mutant cardiac troponin T on cardiac structure and function in transgenic mice. J Clin Invest. 1998 Oct 15;102(8):1498-505
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory