Tg(NPHS2-icre/ERT2)1Dnsh
Transgene Detail
|
Symbol: |
Tg(NPHS2-icre/ERT2)1Dnsh |
Name: |
transgene insertion 1, Farhad R Danesh |
MGI ID: |
MGI:4819592 |
Synonyms: |
podocin-iCreERT2 |
Transgene: |
Tg(NPHS2-icre/ERT2)1Dnsh Location: unknown
|
Alliance: |
Tg(NPHS2-icre/ERT2)1Dnsh page
|
|
|
Transgene Type: |
|
Transgenic (Inducible, Recombinase) |
Inducer: |
|
tamoxifen |
Mutation: |
|
Insertion
|
|
|
Tg(NPHS2-icre/ERT2)1Dnsh expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
NPHS2 (7827) |
|
|
|
|
|
Mutation details: The coding sequences of (improved) icre and a tamoxifen-inducible estrogen receptor, ERT2, were fused in-frame and put under the control of 2.5 kb NPHS2 (human podocin) promoter region. The icre/ERT2 fragment was followed by the bovine growth hormone polyA (bGHpA) sequence. The linearized construct was microinjected into the pronuclei of fertilized C57BL/6 eggs. Three of four founders successfully transmitted the transgene to their offspring.
(J:162633)
|
Inheritance: |
|
Not Specified |
|
Generation of Tg(NPHS2-icre/ERT2)1Dnsh. |
|
|
Activity: |
Tissue activity of this recombinase allele
|
Driver:
|
NPHS2
(human)
|
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:162633 Wang J, et al., Tamoxifen-inducible podocyte-specific iCre recombinase transgenic mouse provides a simple approach for modulation of podocytes in vivo. Genesis. 2010 Jul;48(7):446-51 |
All: |
12 reference(s) |
|